Xinwei (Dorothy) Hou is a PhD Candidate at Capital Center for Children’s Health Care, Capital Medical University. She earned her Master’s degree in Pediatric Surgery from Southern Medical University in Guangdong, Guangzhou.
Research Interests
Her research focuses on Hirschsprung disease, with particular emphasis on:
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Stromal Remodeling and Mechanical Microenvironment in HSCR — Investigating how mechanical heterogeneity within the intestinal microenvironment regulates stromal cell activation and remodeling.
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iPSC-Based Enteric Nervous System Regeneration and Cell Therapy — The goal is to restore enteric nervous system function and improve intestinal motility through regenerative strategies, with an emphasis on optimizing cell integration, survival, and functional connectivity within diseased intestinal niches.
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Genetic and Molecular Mechanisms of HSCR Pathogenesis — Exploring the genetic architecture of HSCR through integrative multi-omics approaches, including single-cell RNA sequencing, spatial transcriptomics, single-cell proteomics, and metabolomics, to uncover key regulatory networks and disease mechanisms.
Personal Interests
Outside the lab, Xinwei enjoys staying active through sports and outdoor activities, and values maintaining a balanced lifestyle alongside research.