Bo Li Laboratory

Welcome to the Bo Li Laboratory at the Precision Regenerative Medicine Research Centre, Macau University of Science and Technology. We study the mechanisms of gut remodeling and regeneration across developmental disorders, acquired intestinal injury, and systemic disease states. Our research integrates stem cell biology, organoid and assembloid models, spatial and single-cell omics, and regenerative therapeutic strategies to understand how tissues lose and regain regenerative competence.

Research

Congenital Gut Disorders

Including Hirschsprung disease (HSCR) and anorectal malformations (ARM), with a focus on developmental remodeling of the intestinal microenvironment.

Acquired Intestinal Injury

Including necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD), with a focus on injury response and regenerative repair.

Systemic and Secondary Injury States

Including liver and biliary disease, sepsis, and aging-related conditions that disrupt intestinal homeostasis and regeneration.